## ----include = FALSE---------------------------------------------------------- knitr::opts_chunk$set( collapse = TRUE, comment = "#>" ) ## ----setup-------------------------------------------------------------------- library(SNPkit) library(snpStats) library(methods) ## ----build-------------------------------------------------------------------- set.seed(123) raw_mat <- matrix( as.raw(sample(1:3, 100, replace = TRUE)), nrow = 10, ncol = 10 ) rownames(raw_mat) <- paste0("ind", 1:10) colnames(raw_mat) <- paste0("snp", 1:10) geno <- new("SnpMatrix", raw_mat) map <- data.frame( Name = colnames(geno), Chromosome = rep(1, 10), Position = seq_len(10), stringsAsFactors = FALSE ) snp_data <- new( "SNPDataLong", geno = geno, map = map, path = tempfile(), xref_path = "chip1" ) snp_data ## ----summary------------------------------------------------------------------ s <- summary(snp_data) s$n_individuals s$n_snps s$prop_missing print(s) ## ----qc----------------------------------------------------------------------- filtered <- qcSNPs( snp_data, min_snp_cr = 0.8, min_maf = 0.05, snp_mono = TRUE, no_position = TRUE, action = "filter" ) filtered ## ----export------------------------------------------------------------------- out_dir <- file.path(tempdir(), "snpkit_demo") dir.create(out_dir, showWarnings = FALSE) savePlink( filtered, path = out_dir, name = "demo", run_plink = FALSE, chunk_size = 5 ) list.files(out_dir, pattern = "demo")